Weiliam Chen 

Associate Professor
 

Research Focus

Weiliam Chen’s research is in the application of biocompatible/biodegradable natural carbohydrates to address various clinically relevant biomedical problems including wound repair, cerebral aneurysm, arteriovenous malformation, abdominal aortic aneurysm endoleak and controlled delivery of therapeutic agents (small molecules, proteins and DNA) through interdisciplinary research efforts. Localized application provides the maximum efficacies of therapeutic agents while minimizing their undesirable effects. Other efforts are targeted towards enhancing the biological responses of both polymeric and metallic medical devices.

Professional Licensure

• Registered Pharmacist (R.Ph.) - Minnesota

Education

• B.S. University of Wisconsin - Madison (Go Big Red !)
   
• M.S. University of Michigan - Ann Arbor (Go Blue !)
   
• Ph.D. University of Michigan - Ann Arbor(Go Blue ! Again.)

Appointments

• 2006 – Current
  Associate Professor, Department of Biomedical Engineering, State University of New York-Stony Brook

• 2005 – Current
  Co-Founder, EndoMedix, Inc., Long Island High Technology Incubator, Stony Brook, NY

• 2000 – 2005
  Assistant Professor, Department of Biomedical Engineering, State University of New York-Stony Brook

• 2001 – 2004
  **Manager, Clear Solutions, Inc., Stony Brook, NY
  (**joint-appointments with SUNY-Stony Brook from 2001 to 2004)

• 1999 – 2000
  *Senior Scientist, Clear Solutions, Inc., Stony Brook, NY
  (*joint-appointments with SUNY-Stony Brook during 2000)

• 1997 – 1998
  Assistant Research Scientist/Research Assistant Professor, Joseph Stokes, Jr. Research Institute, Children's Hospital of Philadelphia / School of Medicine, University of Pennsylvania Medical Center, Philadelphia, PA

• 1996 – 1997
  Research Investigator, Medical School, University of Michigan - Ann Arbor, MI

Courses

• BME 504          Biomaterials Science and Engineering

• BME 606          Therapeutic Technologies in Drug and Gene Delivery

• BME 430          Engineering Approaches in Drug Delivery Systems

Publications

Click here to search Weiliam Chen's PubMed listings

Peer-Reviewed Publications

• Cloyd JM, Malhotra NR, Mauck RL, Weng L, Chen W, Elliott DM. “Mechanical Characterization of Biocompatible Hydrogel Formulations in Human Vertebrate Motion Segments,” Eur Spine J. 2007. (in press)

• Weng LH, Pan H, Chen W. “Crosslinked hydrogels composed of partially oxidized hyaluronan and gelatin: in vitro and in vivo responses,” J Biomed Biomater Res. Part A. 2007. (in press)

• Weng LH, Chen X, Chen W. “Rheological Characterization of in situ Crosslinkable Hydrogels Formulated from Oxidized Dextran and Carboxyethyl Chitosan, ” Biomarcromolecules. 8(4):1109-1115, 2007.

• Zhao PC, Jiang HL, Pan H, Zhu KJ, Chen W. “Biodegradable fibrous scaffolds composed of gelatin coated poly(ε-caprolactone) prepared by coaxial electrospinning,” J Biomed Biomater Res. Part A. 83A:372-382, 2007.

• Wu J, Wang X, Keum JK, Zhou H, Gelfer M, Avila-Orta C-A, Pan H, Chen W, Chiao SM, Hsiao BS, Chu B. “Water soluble complexes of chitosan-g-MPEG and hyaluronic acid,” J Biomed Mater Res, Part A, 80(4):800-812, 2007.

• Turner WS, Schmelzer E, McClelland R, Chen W, Wauthier E, Reid LM. “Human hepatoblast phenotype maintained by hyaluronan hydrogels,” J Biomed Mater Res B, Appl Biomater. 82(1):156-168, 2007.

• Pan H, Jiang HL, Chen W. “Interaction of dermal fibroblast with electrospun composite biodegradable polymer scaffolds prepared from dextran and poly-lactide-co-glycolide,” Biomaterials,. 27(17):3209-3220, 2006.

• Azeloglou E, Yun YH, Saltman AE, Krukenkamp I, Chiang FP, Chen W, Gaudette G. “High resolution mechanical function in the intact porcine heart: mechanical effects of pacemaker location, ” J Biomechanics, 39:717-725, 2006.

• Jiang HL, Hu YQ, Li Y, Zhao PC, Zhu KJ, Chen W. “A facile technique to prepare biodegradable coaxial electrospun nanofibers for controlled release of bioactive agents” ” J Controlled Rel, 108:237-243, 2005.

• Jiang HL, Wang YJ, Huang Q, Li Y, Xu CN, Zhu KJ, Chen W. “Biodegradable Hyaluronic Acid/N-Carboxyethyl Chitosan/Protein Ternary Complexes as Implantable Carriers for Controlled Release of Protein, ” Macromol Biosci,. 5:1226-1233, 2005.

• Yun YH, Jiang HL, Chan R, Chen W. “Sustained Release of PEG-g-Chitosan complexed DNA from poly-lactide-co-glycolide microspheres, ”  J Biomater Sci, Polymer ed, 16(11):1359-1378, 2005.

• Kim A, Yellen P, Yun YH, Chen W. “Delivery of a vector encoding mouse hyaluronan synthase 2 gene transfer via a crosslinked hyaluronan film, ” Biomaterials, 26(13):1586-1593, 2005.

• Jiang HL, Fang DF, Hsiao B, Chu B, Chen W. “Optimization and characterization of dextran Membranes prepared by electrospinning, ” Biomarcromolecules, 5(2):326-333, 2004.

• Jiang HL, Fang DF, Hsiao B, Chu B, Chen W. “Preparation and characterization of ibuprofen-loaded poly(lactide-co-glycolide) / poly(ethylene glycol)-g-chitosan electrospun membranes, ” J Biomater Sci, Polymer Ed, 15(3):279-296, 2004.

• Yun YH, Goetz D, Yellen P, Chen W. “ Hyaluronan microspheres for sustained gene delivery and site-specific targeting, ” Biomaterials, 25(1):147-157, 2004

• Kim A., Checkla D, Dehazya P, Chen W. “ Characterization of hyaluronan-DNA matrices for sustained gene transfer,” J Controlled Rel, 90(1):81-95, 2003

• Klugherz BD, Jones PL, Cui X, Chen W, Meneveau NF, DeFelice S, Connolly J, Wilensky R, Levy R. “ Gene delivery from a DNA-controlled release stent in porcine coronary arteries,” Nature Biotechnology, 18(11):1181-1190, 2000

• Klugherz B, Meneveau N, Chen W, Wade-Whitaker F, Papandreou G, Levy R, Wilensky R. “ Sustained intramural retention and regional redistribution following local vascular delivery of PLGA and liposomal nanoparticulate formulations containing Probucol,” J Cardiovasc Pharm Therap, 4(3):167-174, 1999

• Labhasetwar V, Bonadio J, Goldstein S, Chen W, Levy RJ. “ A DNA controlled release coating for gene transfer: transfection in skeletal and cardiac muscle.” J Pharm Sci, 87(11):1347-1350, 1998

• Gott JP, Girardot MN, Girardot JM, Hall JD, Whitlark J, Horsley WS, Chen W, Levy RJ, Schoen FJ and Guyton RA. “ Refinement of the alpha amino oleic acid bioprosthetic valve anticalcification technique.” Ann Thorac Surg, 64:50-58, 1997

• Vyavahare NR, Chen W, Joshi RR, Lee CH, Hirsch D, Levy J, Schoen FJ and Levy RJ. “Current progress in anticalcification for bioprosthetic and polymeric heart valves, ” Cardiovasc Pathol, 6:219-229, 1997

• Chen W, Schoen FJ, Myers DJ and Levy RJ. " Synergistic inhibition of the calcification of porcine aortic root with preincubation in FeCl3 and ,-amino oleic acid in a rat subdermal model, " J Biomed Mater Res, 38:43-48, 1997

• Levy RJ, Labhasetwar V, Song C, Lerner E, Chen W, Vyavahare N, Qu X. “ Polymer drug delivery systems for treatment of cardiovascular calcification, arrhythmias and restenosis, “ J Controlled Rel, 36:137-147, 1995

• Chen W, Kim JD, Schoen FJ and Levy RJ. " 2-Amino oleic acid surfactant derivatization of bioprosthetic tissue for counteracting mineralization-a comparison of its performance in different animal models, " Cells and Materials., 4:419-428, 1995

• Villa AE, Guzman LA, Chen W, Golomb G, Levy RJ, Topol EJ. " Local delivery of dexamethasone for prevention of neointimal proliferation in a rat model of balloon angioplasty. " J Clin Invest, 93:1243-1249, 1994

• Chen W, Kim JD, Schoen FJ and Levy RJ. " Effects of 2-amino oleic acid exposure conditions on the inhibition of calcification of glutaraldehyde cross-linked porcine aortic valve, " J Biomed Mater Res, 28:1485:1495, 1994

• Chen W, Schoen FJ and Levy RJ. " Preincubation of glutaraldehyde pretreated porcine bioprosthetic heart valve in 2-amino oleic acid: in vitro and in vivo study of mechanism of efficacy, " Circulation., 90:323-329, 1994

• Chen W and Yang VC. " A test strip based heparin assay: aspects for clinical laboratory application, " CHIMICAoggi Int J Chem and Biotech, 9(10):43-49, 1992

• Yang VC and Chen W. " A protamine-mediated heparin sensing device, " ASAIO Trans, 37:292-294, 1991

• Chen W and Yang VC." Versatile, non-clotting based heparin assay requiring no instrumentation, " Clin Chem, 37(6):832-837, 1991

• Marmur A, Chen W and Zografi G. " Characterization of particle wettability by the measurement of flotability, " J Coll Interf Sci, 113(1):114-120, 1986

   

Non-Peer-Reviewed Publications

• Chen W. “Sustained Release of Plasmid DNAs Encoding PDGF and HAS2 from Crosslinked Hyaluronan Matrices and Films, edited by Friedmann T and Rossi J. “In DNA Delivery/Gene Transfer Manual, Cold Spring Harbor Laboratory Press, pp515-520, 2006.

• Yun YH, Kim A, Chen W. “The Application of Derivatized Hyaluronan for Non-Viral Gene Therapy,” In Hyaluronan: Structure, Metabolism, Biological Activities, Therapeutic Applications. edited by Hascall VC, Balazs EA. Matrix Biology Institute, pp447-450, 2005.

• Yun YH, Chen W. “Hyaluronan Microspheres for Sustained Gene Delivery,” In: Polymeric Gene Delivery Vehicles: Principles and Applications, edited by Amiji MM, CRC Press, Baton Rouge, pp474-486, 2005.

• Kim A, Checkla DM, Wen D, Dehazya P, Chen W. “ Hyaluronan Matrix for Sustained Gene Transfer to Enhance Wound Repair,” In: Polymeric Gene Delivery Vehicles: Principles and Applications, edited by Amiji MM, ed., CRC Press, Baton Rouge, pp589-610, 2005.

• Chen W, Checkla DM, Dehazya P. “Hyaluronan DNA delivery matrix for gene transfer,” In: Hyaluronan,Chemical, Biochemical and Biological Aspects, Volume 1, edited by Kennedy JF, Phillips GO, Williams PA, Hascall VC, Woodhead Publishing Ltd., Cambridge, pp 305-312, 2001.

• Chen W, Schwendeman SP, Labhasetwar V and Levy RJ. “Techniques in cardiovascular drug delivery: surfactant derivatization, polymer implants and iontophoresis, " Polymer Site - Specific Pharmacotherapy, edited by Domb AJ, John Wiley and Sons, New York, pp 221-242, 1994.

• Chen W and Yang VC. “The development of a cellulosic material based method for heparin therapy monitoring, " Cosmetic and Pharmaceutical Polymer Applications (the American Chemical Society Symposium Series), edited by Charles G. Gebelein, Plenum Press, New York, pp 329-364, 1992.

Selected Abstracts

• Pan H, Jiang HL, Chen W. “"A Fibroblast/Macrophage Co-culture Model for in vitro Investigation of Material Biocompatibility and Biodegradability,” 8th New Jersey Symposium on Biomaterials Science, New Brunswick, November, 2006.

• Falabella C, Chen W. “"Prevention of postsurgical adhesions by implementation of a cross-linked hyaluronan film,”” 8th New Jersey Symposium on Biomaterials Science, New Brunswick, November, 2006.

• Malhotra N, Beckstein J, Cloyd JM, Weng LH, Chen W, Elliot DM. “A novel injectable nucleus pulposus implant to restore motion segment mechanics,” AANS Meeting, 2006.

• Malhotra N, Beckstein J, Cloyd JM, Johannessen WJ, Chen W, Elliot DM. “Injectable hydrogels to support nucleus pulposus function,” Pennsylvania Neurological Society Meeting, Harrisburg, July 2006.

• Turner W, Chen W, Reid L. “Hyaluronan hydrogels are excellent substrata for expansion of human liver cells (142251),” Conference Proceeding. Annals of Biomedical Engineering, 2005.

• Falabella C, Raven R, Chen W. “Modulation of BSA release from novel microsphere fabricated with PEG-grafted-chitosan and PLGA blend (142078),” Conference Proceeding. Annals of Biomedical Engineering, 2005.

• Chen W. “in vitro and in vivo Assessments of the efficacies of hyaluronan vehicles designed for sustained release of pDNA encoding VEGF, PDGF and HAS-2,” ACS Conference, PACIFICHEM 2005, Macromolecular Chemistry Section, New Delivery Systems for Controlled Drug Release from Naturally Occurring Materials, Honolulu, December 2005.

• Frame MD, Chen W, Jiang HL, McCusker E, Valane PD, Pan Y. “Chronic growth factor delivery with engineered microspheres predictably changes arteriolar responses,” International Congress of Physiological Sciences with Experimental Biology, San Diego, April 2005.

• Frame M, Chen W, Jiang HL, McCusker E, Valane P, Pan Y. “ Chronic growth factor delivery with engineered microspheres predictably changes arteriolar responses, “ American Heart Association Annual Meeting, 2004.

• Frame M, Chen W, Jiang HL, Lin X. “ Acute and chronic effects of PLGA microsphere bFGF delivery on Arteriolar responses on hamster cheek pouches, “ American Heart Association Annual Meeting, 2003.

• Yun YH, Kim A, Frame M, Lin X, Checkla D, Wen D, Dehazya P, Chen W. “ Modulation of gene transfer by crosslinked hyaluronan, “ Proceedings of Hyaluronan 2003, 94, 2003.

• Azeloglu EU, Yun YH, Chen W, Chiang FP, Krukenkamp IB, Gaudette GR “Determination of regional diastolic function in the ischemic heart,” 6.P5.116, Annals of Biomedical Engineering, 2003.

• Jiang HL, Chen W. “ Hydrophobic/hydrophilic electrospun membranes for biomedical applications, “ in Division of Polymeric Materials: Science and Engineering, 226th American Chemical Society National Meeting, New York, September 7-11, 2003.

• Azeloglu EU, Chen W, Yun YH, Krukenkamp IB, Chiang FP, Gaudette GR “Developing a measurement of diastolic function using epicardial deformation,” Proceeds of SEM Student Symposium on Mechanics and Packaging, Worcester, MA, 2003. [voted the best poster of the meeting]

• Chen W, Yun YH, Charubin M. “Sustained delivery of VEGF DNA for angiogenesis.” Proc. Cont. Rel. Soc, S32, 2002.

• Yun YH, Yellen P, Chen W. “A hyaluronic acid gene delivery microspheres with sustained release and transfection capabilities,” S-97, Annals of Biomedical Engineering, 2001.

• Komatsu DE, Yun YH, Chen W. “Characterization of a novel film for the controlled release of plasmid DNA,” Annals of Biomedical Engineering, S-96, 2001.

• Chen W, Kim A. “Hyaluronan wafer for prolonged gene delivery,” Annals of Biomedical Engineering, S-96, 2001.

• Chen W, Wen D, Checkla DM, Charubin M. “Hyaluronic acid microparticles for sustained gene transfer,” Annals of Biomedical Engineering, S-22, 2000.

• Chen W, Dehazya P. “ Hyaluronan DNA delivery matrix for gene transfer, “ Proceedings of Hyaluronan 2000, 136, 2000.

• Klugherz BD, Jones PL, Chen W, Meneveau NF, Wade-Whitaker F, Levy R, Wilensky RL. “ Successful gene transfer to swine coronary arteries using a polymer-coated DNA-eluting stent,” Eur. Heart J., 20(Suppl):367, 1999.

• Chen W, Dehazya P. “Hyaluronan film and matrix for sustained gene transfer,” Advancements in Tissue Engineering (IBC Industry Symposium), Boston, 1999.

• Klugherz B, Chen W, Meneveau N, Jones PL, Wade-Whitaker F, Levy R, Wilensky R. “Successful gene transfer to the arterial wall using a DNA-eluting polymer-coated intracoronary stent in swine,” American College of Cardiology 47th Scientific Session, 1999.

• Klugherz W, Meneveau N, Chen W, Wade-Whitaker F, Papandreou G, Levy R, Wilensky R. “Redistribution of nanoparticle-encapsulated probucol following local vascular delivery using the Cresendo catheter,” American College of Cardiology 47th Scientific Session, 1999.

• Klugherz W, Meneveau N, Chen W, Papandreou G, Wilensky R, Levy R. “ Local delivery of Biodegradable nanoparticles,” American Heart Association 71st Scientific Session, Dallas, 1998.

• Anand V, Chen W, Miyamoto T, Levy RJ, Fox J. “Dominant negative receptor inhibition of FGF signaling provokes cardiomyocyte apoptosis in vivo,” American Heart Association 71st Scientific Session, Dallas, 1998.

• Chen W, Cohen H, Cui XM, Golomb G, Levy RJ. “DNA nanoparticle for gene transfer,” Proc. Cont. Rel. Soc., 374-375, 1998.

• Chen W, Labhasetwar V, Goldstein S, Bonadio J, Levy R. “DNA coating for gene transfer,” Proc. Cont. Rel. Soc., 372-373, 1998.

• Chen W, Cohen C, Labhasetwar V, Cui XM, Bonadio J, Goldstein S, Levy R. “Sustained DNA Release Systems for Site Specific Gene Transfer,” NIH Symposium in Bioengineering - Building the Future of Biology and Medicine, p45 Bethesda, 1998.

• Chen W, Gopal R, Schoen FJ, Levy RJ. “Ethane hydroxy bisphosphonate (EHBP) for inhibiting calcification of Glutaraldehyde crosslinked bioprosthetic aortic wall. Trans. Soc. Biomater., 294, 1998.

• Gott JP, Girardot M-N, Girardot J-MD, Hall JD, Whitlark J, Horsely SW, Lynne MA, Dorsey MA, Levy RJ, Chen W, Schoen FJ, Guyton RA. “The modified alpha amino oleic acid process protects glutaraldehyde preserved porcine valve leaflet tissue in a chronic ovine model of accelerated bioprosthetic calcification,” 4th Scientific Meeting of International Association for Cardiac Biological Implants, p14, Washington DC, 1997.

• Panek R, Chen W, Hamby J, Batley B, Levy R, Keiser J. “Prolonged vascular effects with drug loaded nanoparticles,” 24th Meeting of the Controlled Release Society, Stockholm, Sweden, 1997.

• Chen W, Schoen FJ, Levy RJ. “Sodium hydroxide for inhibiting calcification of glutaraldehyde crosslinked bioprosthetic heart valves,” Trans. Soc. Biomater., 42, 1997.

• Levy RJ, Vyavahare N, Joshi R, Chen W, Hirsch D, Levy J, Schoen F. “Current progress in anti-calcification and alternative fixation methodology for bioprosthetic valves,” Fifth Biennial Meeting of International Society for Applied Cardiovascular Biology, 1996.

• Chen W, Myers DJ, Levy RJ. “Synergistic inhibition of calcification of bioprosthetic heart valves with preincubation in ferric ion and ,-amino oleic acid,” Trans. Soc. Biomater., 432, 1996.

• Chen W, Kim JD and Levy RJ. " Dose-dependent anticalcification effect of 2-amino oleic acid for glutaraldehyde cross-linked bioprosthetic tissues, " Transactions of American Chemical Society, Symposium of the Division of Industrial and Engineering Chemistry: polyamino acids, the emergence of life, and industrial applications, pp11, 1994.

• Chen W, Kim JD, Schoen FJ and Levy RJ. " Covalent modification of bioprosthetic tissues for antimineralization, " Scanning Microscopy International Meeting, 118, 1993.

• Chen W, Guyton RA, Myers DJ and Levy RJ. " Surface modification of stentless bioprosthetic heart valve with 2-amino oleic acid: a viable antimineralization strategy, " Trans. Soc. Biomater., 16:26, 1993.

• Chen W, Guyton RA, Myers DJ, Schoen FJ and Levy RJ. " Inhibition of bioprosthetic calcification by amino oleic acid (in vitro and in vivo sheep implant study), " The Proceedings: AAMI/NHLBI Annual Cardiovascular Science and Technology Conference, 27:75, 1992.

• Villa A, Guzman L, Chen W, Levy RJ and Topol E, " Local delivery of dexamethasone for prevention of neointimal proliferation after balloon injury in rat carotid model, " American College of Cardiology Scientific Session, 42:121,1992.

• Yang VC and Chen W. " A protamine-mediated heparin sensing device, " ASAIO Abstracts, 20:29, 1991.

• Chen W and Yang VC. " Evaluating the effects of plasma components on the performance of a newly developed heparin sensing system," Pharm. Res., 7(9):S-47, 1990.

• Chen W and Yang VC. " Protamine immobilization and capillary migration as an unorthodox approach of heparin sensing, " Pharm. Res., 6(9):S-28, 1989.

Patents

• [Provisional patent]        Chen W, Weng LH, Pan H. “Self-crosslinkable hydrogel systems.”

• [Provisional patent]        Chen W, Libin B, Liebmann J, Polke R. “Nanospheres for ophthalmic drug delivery.”

• [Provisional patent]        Chen W, Libin B, Liebmann J, Polke R.. “Nanosphere composite devices.”

• [Provisional patent]        Chen W, Zahos P, Zahos E “Polymeric drug delivery to degenerative disc diseases.”

• [11/830,125]      (continuation-in-part) “Chen W, Abrahams J. “Biopolymer systems for tissue sealing.”

• [60/899,139]      Malhotra N, Chen W, Elliott. “Disc Augmentation with hyaluronic acid.”

• [11/425,958]      Chen W, Abrahams J, Rozental R. “Formulations and devices for treatment or prevention of neural ischemic damage.”

• [11/530,362]      (continuation-in-part) Chen W, Abrahams J. “Biopolymer systems for tissue sealing.”

• [11/470,818]      Chen W. “Cosmetic moisturizer formulations.”

• [11/447,794]      Chen W, Abrahams J. “Composition and method for vascular embolization.”

• [60/705,319]      Chen W, Abrahams J. “Modified chitosan for vascular embolization.”

• [11/379,182]      Chen W, Abrahams J. “Biopolymer systems for tissue sealing.”

• [10/364,877]      Chen W, Jiang HL, Yun YH, Saltman AE, Gaudette G. “Biodegradable polymer devices.”

• [09/596,665]      Chen W. “Hyaluronic acid microspheres for sustained gene transfer.”

• [09/596,548]      Chen W, Dehazya P. “Hyaluronic acid film and matrix for sustained gene transfer.”

Grants

• DoD 07SB2-0064, Defense Advanced Research Projects Agency (DARPA), 2008 ($100,000)
  “Tissue Sealant for Intracavitary Non-compressible Hemorrhage.”
  Weiliam Chen (Principal Investigator)

• Phase 2 Innovative Technology Development (ITD) Program NYSTAR, 2008 - 2009 ($80,000)
  “Biocompatible Polymeric Filler as an Adjunct Treatment of Endoluminal Prosthesis to Prevent Abdominal Aortic Aneurysm Endoleak.”
  Weiliam Chen (PI)

• NIH R43, HL088840, 2007 - 2009 ($178,288)
  “Polysaccharide Hydrogel Fillers for Arteriovenous Malformation.”
  Weiliam Chen (PI), Erol Veznaderoglu

• NIH R43, NS059250, 2007 - 2009 ($177,713)
  “In Situ Gelable Filler for Obliteration of Cerebral Aneurysm ”
  Weiliam Chen (PI)

• Innovative Technology Development (ITD) Program NYSTAR, 2007 - 2008 ($40,000)
  “Ophthalmic Localized Drug Delivery.”
  Weiliam Chen (PI)

• New York State Strategic Partnership for Industrial Resurgence/EndoMedix, Inc. 2007 - 2008 ($105,069), “In Vivo Evaluation of Biomaterial Implants.”
  Weiliam Chen (PI)

• NYSTAR, Enhanced Center for Advanced Technology (ECAT), Regenerative Bioengineering: Developing a New Generation of Musculoskeletal Medical Devices, 2007 - 2010 ($240,000)
  “Bioactive Polymer Matrix Media as Advanced Wound Care Systems”
  Weiliam Chen (PI)

• NIH R01, DK068401, 2004 - 2009 ($1,354,500)
  “Wound Repair by Stimulation of Specific Tissue Ingrowth”
  Weiliam Chen (PI), Mary Frame, Yingtian Pan

Completed Projects

• Innovative Technology Development (ITD) Program, NYSTAR, 2006 - 2007 ($40,000)
  “In situ Gelable Carbohydrate Tissue Sealant”
  Weiliam Chen (PI)

• Coulter Foundation, Pilot Program in Translational Research, 2006 - 2007 ($76,000)
  “Biocompatible Polymeric Filler as an Adjunct Treatment of Endoluminal Prosthesis to Prevent Abdominal Aortic Aneurysm Endoleak”
  Weiliam Chen (PI), John Ricotta

• BioSET, Inc., 2003 - 2004 ($17,328)
  “In Vivo Evaluation of Coated Metallic Aneurysm Coil”
  Weiliam Chen (PI)

• NIH R43 NS43809, 2002 - 2003 ($105,000)
  “FGF-Silyl-Heparin Cerebral Aneurysm Coil”
  Paul Zamora, Weiliam Chen (co-I)

• Innovative Technology Development (ITD) Program NYSTAR-031326, 2002 - 2003 ($40,000)
  “Anti-inflammatory films designed to prevent post-operative atrial fibrillation”
  Weiliam Chen (PI), Adam Saltman

• NIH R43 HL66876, 2001 - 2003 ($99,827)
  “Hyaluronan synthase gene transfer to prevent restenosis”
  Weiliam Chen (PI)

• NIH R43 AG17778, 2000 - 2002 ($149,239)
  “Sustained gene transfer for chronic wound healing”
  Weiliam Chen (PI)

• NIH R01 HL65175, 2000 - 2004 ($694,552)
  “Site-specific gene therapy for myocardial angiogenesis”
  Weiliam Chen (PI)

Grant Review Panels

• 2007     U. K. Medical Research Council - Physiological Systems and Clinical Services Board, April

• 2006     NIH ZRG1 BDCN-F11B, June
  NIH ZRG1 MOSS-K12B, April

• 2005     North Carolina Biotechnology Center, November
  NIH ZRG1 MOSS D13, June
  NIH ZRG1 MOSS D12, June
  Israel Science Foundation, April
  NIH ZRG1 MOSS D12, March

• 2004     Israel Science Foundation, April

• 2003     NIH ZRG1SSS-M(01)S, November
  NIH ZRG1SSS-M(01), July
  NIH ZRG1SSS-M(01), March

• 2002     NIH ZAR1RJB-CM1 1, March

• 2001     NIH ZRG1SSS-M(10)B:PAR-01-006, March

Journal Reviewer

• 2007
  Industrial and Chemical Engineering Chemistry Research (1), Journal of Controlled Release (7), Journal of Biomaterial Sciences-Polymer Edition (1), Biomaterials (4), International Journal of Pharmaceutics (2), Biomacromolecules (4), Journal of Biomaterial Applications (1), Pharmaceutical Research (1), BBA Biomembrane (3), Immunological Investigations (1), Stroke (1), Journal of Pharmacy and Pharmacology (1), Biotechnology Progress (1)

• 2006
  Biomacromolecules (3), Biopolymers (1), International Journal of Pharmaceutics (4), Acta Biomaterialia (1), Journal of Macromolecular Science (1), Biomaterials (3), Journal of Controlled Release (8), Journal of Biomaterial Sciences-Polymer Edition (1), Stroke (1)

• 2005
  Stroke (1), Biomaterials (2), Biomacromolecules (1), Macromolecular Bioscience (1), Journal of Controlled Release (3)

• 2004
  Biomacromolecules (4), Macromolecular Bioscience (1), International Journal of Pharmaceutics (1), Biomaterials (4)

• 2003
  Journal of Biomaterial Science, Polymer Edition (2), Biomaterials (2)