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Research Focus
Nanostructured Materials for Applications in Bioseparation,
Drug Delivery and Biosensors. Nature’s ability to assemble
simple molecular building blocks into highly ordered materials, such as
those found in cell membranes, cell nuclei, cytoskeleton, cartilage, or
bone presents many fascinating and unanswered questions. We are interested
in how to tune the interactions of water-soluble building blocks so as
to induce their assembly into useful microstructures much needed for the
next generation of controlled drug delivery, biosensors and DNA sequencing
applications. In particular, we are working on:
- Long-range ordered polyelectrolyte-surfactant microemulsions that
are used as templates for solid nanoporous materials using polymerization
and/or cross-linking strategies. Such materials, because of their well-ordered
porous structure, will allow more efficient molecular separation and
drug delivery.
- We are developing biosensors that are based on biopolymer chiral
liquid crystals and quantum dot colloidal crystals. In both cases the
softness of the systems allows the induction of a strong optical response
to external stimuli. Such sensors should be able to quantitatively detect
and measure analyte concentrations at hormonal levels.
- We are developing methods to perform biomolecular separation on a
chip. Using e-beam lithography we are creating cavity arrays that will
allow to separate biomolecules over several orders of magnitude in molecular
weight. We study diffusion and intramolecular dynamics employing single-molecule
fluorescence.
Education
- 1990 Diploma in physics, Technical University
Munich, thesis advisor: Prof. E. Sackmann
- 1993 Ph.D. in physics (magna cum laude),
Technical University Munich, thesis advisor: Prof. E. Sackmann
Research and Professional Experience
- 1990-1993 Research Assistant, Biophysics,
Research Group, Technical University, Munich
- 1994-1998 Visiting Fellow, National Institutes
of Health, Bethesda, MD
- 1998-2004 Assistant Professor, Department
of Polymer Science and Engineering, Univ. of Massachusetts, Amherst
- 2002-2003 Visiting Professor at New York
University
- 2004-present Assistant Professor, Department
of Biomedical Engineering, SUNY Stony Brook
Honors
- Second prize of the poster competition at the Polymer and Materials
Research Symposium 1993, Bayreuth,Germany
- Visiting Fellow Award (5 years), National Institutes of Health, Bethesda,
MD.
- Research Fellowship (2 years), Deutsche Forschungsgemeinschaft, Germany.
- Schlossmann Award 1995, Max-Planck Society, Germany.
- GenCorp Signature University Award 1999.
- NSF CAREER Award (CMP) 2000-4
- Dillon medal 2003 of the American Physical Society
Professional Activities
- Society Membership:
- 1994 to present German Biophysical Society
- 1994 to present Biophysical Society
- 1995 to present Material Research Society
- 1997 to present American Physical Society
- 2003 to present American Chemical Society
- Referee:
- Annals of Biomedical Engineering
- Physical Review Letters and PRE
- Macromolecules
- Journal de Physique
- Biophysical Journal
- Langmuir
- Proceedings of the National Academy of Science
- Conference & Other Activities:
- Organized workshop “Structure of Biopolymer Solutions: Semiflexibility
with a Twist” during the Biophysical Society Meeting ‘98.
- Complex Fluids symposium co-organizer at the Fall Meeting of
the Material Research Society ’99.
- Discussion leader for the 1999 Gordon Conference on Condensed
Matter Physics.
- Coordinator of IRG 3 ( Aqueous Polymer Assembly ) of the UMass
NSF Material Research Science and Engineering Center
- Faculty of Chemistry-Biology Interface Training Program at UMass
- Co-organizer of the International Symposium on Polyelectrolytes
2004 at UMass Amherst.
Publications
Click
here to search Helmut Strey's PubMed listings
- Peterson M., Strey H., Sackmann E., Theoretical and Phase Contrast
Microscopic Eigenmode Analysis of Erythrocyte Flicker: Amplitudes, J.
Phys II France 2(1992)1273-1285.
- Zilker A., Strey H., Sackmann E., Erythrocyte Membranes: Tethered
Shells with Fluid-Like Deformation Regime, The Structure and Conformation
of Amphiphilic Membranes, Springer Proc. in Physics 66(1992)113-137.
- Käs J., Strey H., Bärmann M., Sackmann E., Direct Measurement
of the Wave-Vector-Dependent Bending Stiffness of Freely Flickering
Actin Filaments, Europhys. Lett., 21(1993)865-870.
- Strey H., Bestimmung elastischer Eigenschaften von Zellmembranen und
Zytoskelett mittels Flickerspektroskopie, Thesis 1993, TU-München.
- Käs J., Strey H., Sackmann E., Direct imaging of reptation for
semiflexible actin filaments, Nature 368(1994)226-229.
- Sackmann E., Käs J., Strey H., The Observation of Polymer Reptation,
Adv. Mater. 6(1994)507-509.
- Rädler J., Feder T.J., Strey H.H., Sackmann E., Fluctuation analysis
of tension-controlled undulation forces between giant vesicles and solid
substrates, Phys. Rev. E. 51(1995)4526-4536.
- *Strey H.H., Peterson M., Sackmann E., Measurement of Erythrocyte
Membrane Elasticity by Flicker Eigenmode Decomposition, Biophysical
J. 69(1995)478-488.
- Podgornik R., Strey H.H., Rau D.C., Parsegian V.A., Watching molecules
crowd: DNA double helices under osmotic stress, Biophys. Chem. 57(1995)111-121
- Rädler J., Strey H., Sackmann E., On the Phenomenology and Kinetics
of Lipid Bilayer Spreading on Hydrophilic Surfaces, Langmuir 11(1995)4539-4548.
- Käs J., Strey H., Tang J.X., Finger D., Ezzell R., Sackmann E.,
Janmey P.A., F-actin, a model polymer for semiflexible chains in dilute,
semidilute, and liquid crystalline solutions, Biophys. J. 70(1996)609-625.
- Podgornik R., Strey H.H., Gawrisch K., Rau D.C., Rupprecht A., Parsegian
V.A., Bond Orientational Order, molecular motion and free energy of
high-density DNA mesophases, PNAS 93(1996)4261-4266.
- Lasic D.D., Strey H.H., Podgornik R., Stuart M.C.A., Frederik P.M.,
DNA - Cationic Liposome Complexes: Structure and Structure-Activity
Relationships, J. Am. Chem. Soc. 119(1997)832-833.
- *Strey H.H., Parsegian V.A., Podgornik R., Equation of State for DNA
liquid crystals: fluctuation enhanced electrostatic double layer repulsion,
Phys. Rev. Lett. 78(1997)895.
- Templeton N.S., Lasic D.D., Frederik P.M., Roberts D.D., Strey H.H.,
Pavlakis G.N., Novel DNA:Liposome Complexes for Increased Systemic Delivery
and Gene Expression, Nature Biotechnology 15(1997)647-652.
- König B., Strey H.H., Gawrisch K., Membrane Lateral Compressibility
Measured by NMR and X-ray Diffraction - Effect of Acyl Chain Polyunsaturation,
Biophys. J. 73(1997)1954-1966.
- *Strey H.H., Podgornik R., Rau D.C., Parsegian V.A., DNA-DNA interactions,
Curr. Opin. Struct. Biol. 8(1998)309-313.
Podgornik R., Strey H.H., Parsegian V.A., Colloidal DNA, Curr. Opin.
Colloid & Interface Science 3(1998)534-539.
- *Strey H.H., Parsegian, V.A., Podgornik R., Equation of State for
Lyotropic Polymer Liquid Crystals: Theory and Experiment, Phys. Rev.
E 59(1999)999-1008.
- *Strey H.H., Wang J., Podgornik R., Rupprecht A., Yu L., Parsegian
V.A., Sirota E., Refusing to Twist: Demonstration of a Line Hexatic
Phase in DNA Liquid Crystals, PRL 84(2000)3105-3108.
- Podgornik R., Strey H.H., Parsegian V.A., Physical forces molding
DNA-lipid complexes, in “Gene Therapy: Therapeutic Mechanisms
and Strategies”, Eds. Templeton N., Lasic D., Marcel Dekker, New
York 2000, p.209-239.
- *Leonard M., Hong H.,Easwar N., Strey H.H., Soft matter under osmotic
stress, Polymer 42(2001)5823-5827.
- Ausili P., Strey H.H., Mariani P., X-ray diffraction analysis of four-stranded
helices of guanosine 5’-monophosphate: structural properties and
lyotropic phase behavior, submitted to Biophysical J.
- *Nykypanchuk D, Strey H.H, Hoagland D.A., Brownian Motion of DNA Confined
in a Two-dimensional array, Science 297(2002)987-990.
- Nykypanchuk D., Strey H.H., Hoagland D.A., Single molecule study of
polymer partitioning in model pore geometries, submitted to Physical
Review Letters.
- *C. Stanley, Strey H.H., Poly (ethylene glycol) solution osmotic pressure
measured by analytical ultracentrifugation, Macromolecules 36(2003)6888
–6893.
- * Leonard M., Strey H.H., Phase Diagrams of Stoichiometric Polyelectrolyte-Surfactant
Complexes, Macromolecules 36(2003)9549-9558
- S. Sohn, Strey H.H., Gido S.P., Silk Fibroin under Osmotic Stress,
submitted.
- *Leonard M., Strey H.H., Free energy of transition measurement in
polyelectrolyte-surfactant complexes, in preparation.
- *Nause R., Hoagland D.A., Strey H.H., Thermodynamics of polyelectrolyte-surfactant
complex formation, in preparation.
- *C. Stanley, Strey H.H., Osmotically induced helicity in poly (glutamic
acid), in preparation.
- *W. Wong, Leonard M., Nause R., Strey H.H., Surfactant-templated polysaccharide
hydrogels, in preparation.
- *Stanley C., Hong H., Chiang L.L., Strey H.H., Cholesteric pitch of
DNA liquid crystals, in preparation.
- *Koslova N., Wang J., ,Strey H.H., Anomalous x-ray scattering study
of DNA condensation, in preparation.
- *Koslova N., Strey H.H., Binding studies of Cobalt induced DNA condensation,
in preparation.
Invited Talks:
- Jun. 95: Supercoiled Plasmid DNA as a Possible Chiral and Rodlike
Model Molecule Forming Cholesteric Liquid Crystals, Schlossmann Seminar
of the Max-Planck Society, Mainz.
- Aug. 95: DNA Mesophases: An Osmotic Stress Study, Gordon Conference
on Complex Fluids, NH.
- Feb. 96: Liquid Crystalline Packing of DNA Molecules: An Osmotic Stress
Study, Condensed Matter Seminar, University of Pennsylvania, PA.
- Feb. 96: Liquid Crystalline Packing of DNA Molecules: An Osmotic Stress
Study, 290K Lecture, University of California Berkeley, CA.
- Oct. 96: Chirality, Structure and Free Energy of DNA liquid crystals,
Université Paris Sud, Orsay, France.
- Mar. 97: Chirality, Structure and Free Energy of DNA liquid crystals,
APS March meeting 1997.
- Apr. 97: Chirality, Structure and Free Energy of Biopolymer liquid
crystals, Condensed Matter Seminar at Princeton University, NJ.
- Jun. 97: Biopolymer Liquid Crystals: A new story with a twist, Liquid
Crystals Gordon Conference, NH.
- Dec. 97: Chirality, Structure and Free Energy of Biopolymer liquid
crystals, MRS Fall Meeting, Boston, MA.
- Oct. 98: DNA condensation and applications in gene therapy, Genetic
Therapy Inc., Gaithersburg, MD.
- Feb. 99: DNA condensation and applications in gene therapy, Brookhaven
National Lab, Upton, NY.
- Oct. 99: Soft matter under osmotic stress, James Franck Institute
Colloquium, Univ. of Chicago, IL.
- Apr. 2000: Soft matter under osmotic stress, Columbia University,
NY
- Jun. 2000: Soft matter under osmotic stress, ANL theory institute
on “Structure, dynamics and charge transport in polymeric materials”,
IL.
- Aug. 2000: Biopolymers, Neutron and X-ray scattering school, Argonne
National Labs, Argonne, IL.
- Aug 2001: Anomalous x-ray scattering on Co3+ condensed DNA fibers,
workshop on “Polymer theory vs. experiment”, Telluride,
CO
- Feb. 2002: From micro to nano: polymer transport in long-range ordered
porous materials, Gordon Conference on "Colloidal, Macromolecular
& Polyelectrolyte Solutions", Ventura, CA
- Feb. 2002:, Polymer Colloquium, MIT, Cambridge, MA.
- April 2002: Anomalous X-ray scattering on DNA liquid crystals, NSLS
workshop: Frontiers for Synchrotron Research on Soft Matter and Biomaterials,
NY
- Nov. 2002: DNA Diffusion Observed in a Two-Dimensional Hexagonal Array,
Cornell University, Ithaca, NY
- April 2003: DNA Diffusion Observed in a Two-Dimensional Hexagonal
Array, Solid State Science Committee, National Academy of Sciences,
Washington D.C
- Sep. 2003: Polyelectrolyte-surfactant microemulsions, ACS meeting,
New York, NY
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